The Cochrane US Network is initially includes 11 Affiliate institutions:
- AcademyHealth
- American College of Physicians
- Central Michigan University
- Cornell University
- Mayo Clinic Evidence-based Practice Center
- Penn Medicine Center for Evidence-based Practice
- RTI International – University of North Carolina Evidence-based Practice Center
- Texas Christian University
- University of Chicago Medicine
- University of Colorado Anschutz Medical Campus; and
- University of Maryland School of Medicine