The Cochrane US Network includes 15 Affiliate institutions:
- AcademyHealth
- American College of Physicians
- Central Michigan University
- Cornell University - Division of Nutrition
- Mayo Clinic Evidence-based Practice Center
- Mississippi Centre of Evidence-Based Practice
- Penn Medicine Center for Evidence-based Practice
- RTI International – University of North Carolina Evidence-based Practice Center
- Texas Christian University - School of Nursing
- The Ohio State University - Center for Evidence-based Practice
- The University of Texas MD Anderson Cancer Center
- Tufts University School of Medicine - Public Health Programs
- University of Chicago Medicine
- University of Colorado Anschutz Medical Campus
- University of Maryland School of Medicine
- U.S. GRADE Network